|The following is a list of main and recurring characters in the Blue's Clues series.
- Blue is a blue puppy who leaves clues around the Blue's Clues house on a regular basis. She is voiced by Traci Paige Johnson.
- Steve is the host for the first four seasons. He is played by Steve Burns.
- Joe is Steve's brother, and the host for the final two seasons. He is played by Donovan Patton.
- Mailbox is a joke-loving mailbox who delivers the mail every day. He is voiced by Seth O'Hickory.
- Mr. Salt is a French salt shaker who prepares snacks in the kitchen. He is voiced by Nick Balaban.
- Mrs. Pepper is Mr. Salt's wife. She is voiced by Penelope Jewkes (season 1) and Spencer Kayden (seasons 2-7).
- Paprika is the only daughter of Mr. Salt and Mrs. Pepper. She is voiced by Jenna Marie Castle (seasons 1-3) and Corrine Hoffman (seasons 4-7).
- Tickety is Blue's alarm clock, who loves to count. She is voiced by Kathryn Avery and Kelly Nigh.
- Slippery is a bar of soap who is always sliding around. He is voiced by Cody Ross Pitts (seasons 1-3), Patrick Van Wagnen (seasons 4-7)
- Shovel is a playful shovel. He is voiced by Stephen Schmidt (seasons 1-3), Jonathan Press (seasons 4-5) and Thomas Sharkey (seasons 6-7).
- Pail is Shovel's sister. She is voiced by Marshall Claffy (seasons 1-3), Olivia Zaro (season 3), Julia Wetherell (seasons 3-5) and Nicole Gibson (seasons 6-7).
- Sidetable is the keeper of the Handy Dandy Notebook. She is voiced by LaNaé Allen.
- Magenta is a pink dog and one of Blue's friends. She is voiced by Koyalee Chanda.
- Periwinkle is a cat who lives next door. He is voiced by Cameron Bowen (season 3), Kenny Kim (seasons 4-5) and Jansen Panettiere (seasons 6-7).
- Cinnamon is Paprika's younger brother. He is voiced by Annalivia Balaban.
- The Felt Friends are children made of felt who live in a picture frame.
- Snail is a pink snail who appears in the backgrounds of episodes.